Eysuvis

Short-term prescription treatment for dry eye inflammation

What is Eysuvis?

Eysuvis (loteprednol etabonate ophthalmic suspension 0.25%) is an FDA-approved corticosteroid eye drop for short-term treatment, up to two weeks, of the signs and symptoms of dry eye disease. It may be considered when ocular surface inflammation is contributing to a flare of redness or discomfort.

How does it work?

Loteprednol reduces inflammatory signaling on the ocular surface. Eysuvis uses small drug particles designed to help the medication pass through the tear-film mucus barrier and reach the surface tissues. Its purpose is to control inflammation during a defined treatment period.

A short course can fit within a broader management plan, including when another longer-term therapy is being started. It does not replace an evaluation for eyelid disease, tear deficiency, or other causes of persistent symptoms.

How do we determine whether it is appropriate?

Dr. Jason Besecker examines the cornea, conjunctiva, eyelids, and tear film and reviews your eye health history. Because several infections and other conditions can resemble a dry eye flare, redness alone is not a reason to start a steroid drop.

Tell us about glaucoma, previous pressure increases with steroid use, herpes eye infections, recent procedures, and all other eye medications. These details affect whether a short course is appropriate and how follow-up should be arranged.

Related Question: What Causes Dry Eye?

What have clinical studies shown?

Eysuvis was evaluated in one phase 2 and three phase 3 randomized, vehicle controlled studies. The clinical program supports short-term improvement in conjunctival redness and dry eye discomfort. Responses varied across studies and patients; treatment does not guarantee complete relief.

The published practical guidance discusses using loteprednol 0.25% for periodic flares and as part of a longer-term treatment strategy. A reduction in inflammation is one goal; identifying and managing the factors behind recurring flares remains important.

How is Eysuvis used?

The labeled regimen is one to two drops in each eye four times daily for up to two weeks. Use the number of drops and duration your prescriber recommends.

  • Wash your hands and shake the bottle for two to three seconds before use.
  • Separate Eysuvis from other eye drops by at least five minutes.
  • Remove contact lenses before dosing and wait 15 minutes before reinserting them.
  • Avoid touching the dropper tip to the eye or other surfaces.

Do not extend the course, restart leftover drops, or request repeated courses without an examination. Renewal requires an eye examination and an eye pressure assessment.

What side effects and precautions should I know?

Instillation site pain was reported in 5% of patients. Steroid eye drops can raise eye pressure, contribute to cataracts, delay healing, and mask or worsen infection. Eysuvis is contraindicated in certain viral, fungal, and mycobacterial eye infections. Corneal or scleral thinning requires particular caution.

Contact the clinic promptly for worsening pain, redness, discharge, or vision changes. Discuss pregnancy or breastfeeding and review the complete prescribing information below before treatment.

What happens after the short course?

Follow-up focuses on whether the flare improved and what ongoing care is needed. Your plan may still include treatment for tear instability, eyelid disease, or other examination findings. Bring your current drops and home care routine so we can help you understand which treatments continue after the steroid course ends.

Related Question: How Does a Dry Eye Doctor Choose the Right Treatment?

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Request a comprehensive dry eye evaluation

Ready to take the next step? Let’s find out what is behind your symptoms. Request an evaluation with EnVision Dry Eye Center in Nampa, serving Boise, Meridian, Caldwell, and the Treasure Valley.

EnVision Dry Eye Center
3752 E Amity Avenue, Suite 103
Nampa, Idaho 83687
(208) 490-8823

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Medically reviewed by Jason Besecker, OD, MS
Last updated: October 2026

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Clinical references


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