Tryptyr for Dry Eye Tear Production in Nampa

Prescription support for natural tear production

What is Tryptyr?

Tryptyr (acoltremon ophthalmic solution 0.003%) is an FDA-approved prescription eye drop for the signs and symptoms of dry eye disease. It stimulates tear production through sensory receptors on the ocular surface. At EnVision Dry Eye Center, it is considered as part of a treatment plan based on your examination findings.

How does it support tear production?

The surface of the eye contains cold sensitive receptors called TRPM8 receptors. These receptors participate in signaling that helps regulate natural tearing. Acoltremon activates this pathway to increase tear production. This approach differs from adding artificial tears to the eye or treating inflammation alone.

Dry eye can involve both an inadequate supply of tears and poor tear stability. Increasing tear production may address one part of the problem, while eyelid disease, excessive evaporation, or inflammation may need additional care.

How do we determine whether it is appropriate?

Dr. Jason Besecker reviews your symptoms, current treatments, and ocular surface findings before recommending a prescription. The evaluation considers tear quantity alongside tear quality, eyelid health, and surface damage. A low tear measurement does not by itself determine the entire treatment plan.

What have clinical studies shown?

In the randomized COMET-2 and COMET-3 trials, more patients using acoltremon achieved a meaningful increase in Schirmer tear test measurements than patients using vehicle drops. Increased tear production was observed early in treatment and was maintained across the 90-day studies.

A tear test improvement is an objective measurement; it does not mean every patient becomes symptom free. We assess your comfort, daily function, and examination findings together when deciding whether treatment is helping.

How is Tryptyr used?

The labeled dose is one drop in each eye twice daily, approximately 12 hours apart. Your prescriber will discuss follow-up and ongoing treatment.

Wash your hands and use a single dose vial immediately after opening. One vial can treat both eyes; discard it afterward, even if solution remains.
Separate other eye drops by at least five minutes.
Remove contact lenses before dosing and wait 15 minutes before reinserting them.
Avoid touching the vial tip to your eye or other surfaces. If you miss a dose, continue with the next dose.

What side effects and precautions should I know?

Instillation site pain, including burning or stinging, was reported in 50% of patients in controlled studies. Contact the clinic for troublesome or persistent irritation, worsening redness, pain, or vision changes. Tell your prescriber about pregnancy or breastfeeding; safety and effectiveness below age 18 have not been established.

Follow the package storage instructions carefully. After opening the carton, room-temperature storage is limited to 30 days. The complete prescribing information and instructions for use are linked below.

How does it fit into my care plan?

Bring a list of your prescription drops, artificial tears, and home treatments to your visit. Our team can help organize the schedule and identify which findings each treatment is intended to address. Do not stop another prescribed treatment without discussing the change with your clinician.

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Request a comprehensive dry eye evaluation

Ready to take the next step? Let’s find out what is behind your symptoms. Request an evaluation with EnVision Dry Eye Center in Nampa, serving Boise, Meridian, Caldwell, and the Treasure Valley.

EnVision Dry Eye Center
3752 E Amity Avenue, Suite 103
Nampa, Idaho 83687
(208) 490-8823

Request a Comprehensive Dry Eye Evaluation

Medically reviewed by Jason Besecker, OD, MS
Last updated: October 2026

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